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66 However, the high dose used in the rat study (342.85 mg/m 3 ) was one-eighth the concentration (2813 mg/m 3 ) calculated for air exposure based on the highest concentration of WS-23 (45.1 mg/mL) in our study (assuming a 40 mL puff, 2.5 mg/puff, an aerosol density of 1 g/mL and WS-23 concentration)